Anxiety and sex represent major risk factors for Alzheimer’s disease (AD), with females being more susceptible than males. This K99/R00 identifies the impact of anxiety and sex on the neural ensembles mediating memory loss in a mouse model of AD.
Here, we used an untargeted metabolomics analysis to define system-level alterations following cognitive decline in aged and APP/PS1 (AD) mice
Many Alzheimer’s disease (AD) patients exhibit agitation in the evening or nocturnal hours, often referred to as sundowning. This project uses our activity-dependent tagging line to better understand the circuitry mediating sundowning.
I will examine how education (training) affects cognitive reserve in aging mice.
Grant under review. More details coming soon!
Peripheral infections increase the propensity and severity of seizures in susceptible populations. This study was undertaken to determine whether this seizure hypersusceptibility entails alterations in glutamate signaling.
Individuals at risk of developing Alzheimer's disease (AD) often exhibit hippocampal hyperexcitability. Here, we used a tau mouse model of AD (rTg(TauP301L)4510) to examine the effects of tau pathology on hippocampal glutamate regulation.