Holly Hunsberger, PhD


Projects




The sex-specific impact of anxiety on Alzheimer's disease progression


Anxiety and sex represent major risk factors for Alzheimer’s disease (AD), with females being more susceptible than males. This K99/R00 identifies the impact of anxiety and sex on the neural ensembles mediating memory loss in a mouse model of AD.




Sundowning in Alzheimer's disease


Many Alzheimer’s disease (AD) patients exhibit agitation in the evening or nocturnal hours, often referred to as sundowning. This project uses our activity-dependent tagging line to better understand the circuitry mediating sundowning.




Using "education" to enhance cognitive reserve


I will examine how education (training) affects cognitive reserve in aging mice.


Combinatorial drug therapy for Alzheimer's disease


Silo Pharma Enters into Sponsored Research Agreement with Columbia University to Develop Psychedelic Therapeutics for Alzheimer’s Disease




Divergence in the metabolome between natural aging and Alzheimer's disease


Here, we used an untargeted metabolomics analysis to define system-level alterations following cognitive decline in aged and APP/PS1 (AD) mice




Glutamate's role in inflammation and seizure susceptibility


Peripheral infections increase the propensity and severity of seizures in susceptible populations. This study was undertaken to determine whether this seizure hypersusceptibility entails alterations in glutamate signaling.




Glutamate's role in Alzheimer's disease


Individuals at risk of developing Alzheimer's disease (AD) often exhibit hippocampal hyperexcitability. Here, we used a tau mouse model of AD (rTg(TauP301L)4510) to examine the effects of tau pathology on hippocampal glutamate regulation.