Holly Hunsberger, PhD


Behavioral Neuroscientist (she/her)


Curriculum vitae


hh2694​@cumc​.columbia​.edu

646-774-7316

Psychiatry/Systems Neuroscience


Columbia University/ New York State Psychiatric Institute


1051 Riverside Drive, Unit 87
736 KOLB Annex




Holly Hunsberger, PhD


Behavioral Neuroscientist (she/her)


Contact

Holly Hunsberger, PhD


Behavioral Neuroscientist (she/her)


Curriculum vitae

hh2694​@cumc​.columbia​.edu

646-774-7316

Psychiatry/Systems Neuroscience


Columbia University/ New York State Psychiatric Institute


1051 Riverside Drive, Unit 87
736 KOLB Annex




About


"Somewhere something incredible is waiting to be known." ~Carl Sagan

I am a postdoctoral research scientist with a dual appointment at Columbia University and the New York State Psychiatric Institute (NYSPI/RFMH). I received my PhD from West Virginia University under the mentorship of Dr. Miranda Reed. There, I studied glutamate’s role in Alzheimer’s disease pathology using novel microelectrode array technology. I am now in Dr. Christine Denny’s laboratory, where I recently received a K99/R00 to study the sex-specific impact of anxiety on Alzheimer’s disease progression. Additionally, I have a fellowship with the Columbia Technology Ventures office where I work on early stage technology assessments, writing marketing abstracts, and preparing marketing campaigns. More recently, I was awarded SfN’s trainee development award and was one of the top 15 candidates in the first SfN leadership development program. When I'm not in the laboratory (pre COVID), I enjoy teaching cycling classes or singing for sporting events as fitness and music are my longtime hobbies.

ON THE JOB MARKET! 

Publications


Behavioral and neurobiological effects of GnRH agonist treatment in mice-potential implications for puberty suppression in transgender individuals.


Anacker C, Sydnor E, Chen BK, LaGamma CC, McGowan JC, Mastrodonato A, Hunsberger HC, Shores R, Dixon RS, McEwen BS, Byne W, Meyer-Bahlburg HFL, Bockting W, Ehrhardt AA, Denny CA


Neuropsychopharmacology, 2020


Divergence in the metabolome between natural aging and Alzheimer's disease


Hunsberger HC, Greenwood BP, Tolstikov V, Narain NR, Kiebish MA, Denny CA


Scientific Reports, vol. 10(1), 2020


Prophylactic (R,S)-ketamine selectively protects against inflammatory stressors


Mastrodonato A, Cohensedgh O, LaGamma CT, McGowan JC, Hunsberger HC, Denny CA


Behavioral Brain Research, 2020


The role of APOE4 in Alzheimer's disease: strategies for future therapeutic interventions


Hunsberger HC, Pinky PD, Smith W, Suppiramaniam V, Reed MN


Neuronal Signaling, vol. 3(2), 2019


Peripheral viral challenge elevates extracellular glutamate in the hippocampus leading to seizure hypersusceptibility


Hunsberger HC, Konat GW, Reed MN


Journal of Neurochemistry , vol. 141(3), 2017, pp. 341-346


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Projects




The sex-specific impact of anxiety on Alzheimer's disease progression


Anxiety and sex represent major risk factors for Alzheimer’s disease (AD), with females being more susceptible than males. This K99/R00 identifies the impact of anxiety and sex on the neural ensembles mediating memory loss in a mouse model of AD.




Divergence in the metabolome between natural aging and Alzheimer's disease


Here, we used an untargeted metabolomics analysis to define system-level alterations following cognitive decline in aged and APP/PS1 (AD) mice




Sundowning in Alzheimer's disease


Many Alzheimer’s disease (AD) patients exhibit agitation in the evening or nocturnal hours, often referred to as sundowning. This project uses our activity-dependent tagging line to better understand the circuitry mediating sundowning.




Using "education" to enhance cognitive reserve


I will examine how education (training) affects cognitive reserve in aging mice.


Combinatorial drug therapy for Alzheimer's disease


Grant under review. More details coming soon!


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Posts


Apr 25, 2021


Female brain, anxiety, Alzheimer's: towards a new paradigm. Holly Hunsberger | International Science


(Link)



Sep 14, 2020


Cognitive training to enhance cognitive reserve in aging mice


(Link)



May 2, 2020


Alzheimer's Trainee Happy Hour #4, Holly Hunsberger


Alzheimer's Afternoons seminar series. Every Tuesday and Thursday 3pm EDT. On Friday they have happy hour with two talks from trainees. (Link)



Apr 27, 2020


Holly Hunsberger Shares Insight about SfN’s TPDA


The Leadership Development Program (LDP) is a pilot initiative focused on building the skills, knowledge, and confidence in trainees so that they can effectively perform as leaders. Participants are selected from the highest-ranking graduate students a... (Link)


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Sep 11, 2017


ADDF - Holly Hunsberger - 2017 ADDF Young Investigator Scholar


Holly Hunsberger, 2017 ADDF Young Investigator Scholar, introduces her work to be presented at the 18th International Conference on Alzheimer's Drug Discovery (September 11-12, 2017, Jersey City, NJ) - review additional information at alzdiscovery.org/... (Link)


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